Cytokine active disulfide-HMGB1 increased during severe macrophage activation syndrome
نویسندگان
چکیده
Introduction Macrophage activation syndrome (MAS) is a lifethreatening complication of childhood systemic inflammatory disorders. HMGB1 is a nuclear protein that extracellularly orchestrates key events in inflammation. Recent data revealed that different redox states of three cysteines within HMGB1 render it with mutually exclusive activities: reduced all-thiol-HMGB1 exerts chemotactic activity, disulfide-HMGB1 cytokine-inducing effects, and terminally oxidized sulfonyl-HMGB1 without inflammatory activity.
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